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Section IV: NORMAL METABOLISM

Metabolism is defined as the sum total of all the chemical reactions required for all function. 

To better understand the metabolic changes in the surgical patient, it is best to compare normal metabolism, that due to starvation and that due to stress in the surgical patient.  The terminology used in describing metabolism, is presented.

 

Definitions

Energy: The capacity to do work

 

Energy Production:  defined in terms of standard Energy units produced per time, or Oxygen Consumed per time, as oxygen is required for Energy production.

 

Energy Consumptions: Energy used/time (e.g. Kcal/hr or ml O2 /min.)

 

Kilocalorie – standard measure of the quantity of Energy obtained from nutrients (often referred to as a Calorie) (e.g. One gram Carbohydrate produces 3.3 Kcal)

 

Calorie: term used interchangeably with Kcal.

 

Energy Production: term used to quantify the amount of energy generated over time.  Since 95% of the oxygen used is for energy production, oxygen consumed can also be used as a measure of energy as can the Kilocalorie (Calorie).

 

Energy Consumed: quantifies the energy used. Energy consumed, in the form of oxygen used or Calories burned is used to determine the patients nutrient requirements.

 

Metabolism: Sum (body) total of all chemical reactions required for cell function – an energy requiring process.

 

Hyper-metabolism: increase in metabolic rate above normal for a specific activity level.

 

Anabolism: Constructive Metabolism: protein synthesis and new tissue formation.

 

Catabolism: Destructive Metabolism: protein breakdown producing tissue degradation.

 

Protein-Energy Malnutrition (PEM) is defined by inadequate intake of energy and protein is the most common form of malnutrition in the acutely injured, chronically ill or incapacitated respiratory dysfunction populations.

The initial symptoms of fatigue (cell energy crisis) are followed by progressive weight loss including fat but predominantly lean mass.

 

Unintentional Weight Loss6-10

Loss of 10% of actual body weight over a 6 month period or greater than 5% over 30 days is usually considered to be the definition for weight loss producing a significant health risk.

 

Because unintentional weight loss is often an associated factor in malnutrition, as well as injured or ill patients, and is easy to monitor.  The degree of weight loss is used as a marker of the degree of malnutrition.  Weight loss itself is used as a medical quality assurance marker for adequacy of nutrition in patient populations at risk.  The degree of morbidity including poor wound healing and development of ongoing respiratory disease increases as the degree of weight loss increases.

 

Hormonal Regulations
Hormones regulate the metabolic pathways.  These chemical messengers control nutrient processing and control the rate of anabolism and catabolism.
 
Hormones:

Chemical messengers from endocrine system

Control nutrient processing

Maintain energy balance

Control rate of protein synthesis (anabolism) and protein breakdown (catabolism)

 
Key Hormones Regulating Metabolism:

       Insulin  

Controls glucose to energy

Converts excess glucose to fat

Converts amino acid to protein (anabolic)

     Catecholamines

Increases metabolic rate

Anti-insulin: increases blood glucose

     Cortisol

Stimulates gluconeogenesis

Causes protein breakdown (catabolic)

      Growth Hormones

Stimulate protein synthesis (anabolic)

Anticatabolic

Increases blood glucose

      Glucagon

Stimulates glucose production

Catabolic

       Testosterone

Increases protein synthesis (anabolic)

Normal metabolic activity is shown.  Normal energy expenditure is about 25 cal/kg/day.  Carbohydrates provide most of the fuel (60%) for energy followed by fat. (25-30%)  Very little protein is used for fuel, most being used for protein synthesis.
 
Figure 4:

 

Legend: Normal metabolic activity is controlled by hormonal balance.  The energy compartment is fueled mainly by carbohydrates and fat while the lean mass or protein compartment  is maintained by ingested protein. Therefore the normal partitioning of macronutrients is carbohydrate and fat to energy and protein, to the protein synthesis.  Anabolic hormones maintain this balance.
 
Figure 5:

 

Legend: The hormonal environment maintains the activity in these compartments of energy production and protein synthesis.  Anabolic activity maintains the protein synthesis pathway.

 

[Body Composition Changes][Metabolic Response]

 

 

 


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