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V continued

 

E: TIME COURSE

Nutritional intake is required only in this time course and until the catabolic state has resolved and any malnutrition and involuntary weight loss has been corrected, especially any protein or lean mass losses. 

The time course of the increased energy and protein demands is weeks to months, depending on the insult.  Patients are usually discharged before resolution of the
stress response”.  Nutritional support needs to be continued in the post-discharge patient until the recovery phase has been initiated and prior energy and protein losses can be restored.

The degree and the time course of the hypermetabolic state are shown.  The process can persist for weeks to months.

 

The rate and time course protein breakdown is shown using Nitrogen loss in the urine as a marker.  This process can last weeks to months.

 
The addition of further anabolic stimuli, especially resistance exercise and anabolic hormones can assist in optimizing nutrition, correcting malnutrition, attenuating catabolism and any lean mass loss.

Legend: The rate of protein loss is 5 times faster than the rate of restoration after a burn injury.  However, the addition of an anabolic agent to nutrition markedly increases lean mass restoration.

 

 

 

 

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